8 In 2015, 2224 LM cases were reported in Europe, with a total mortality of 18.8%. 7 From 1996 to 2005, LM accounted for 30% of lethal food-borne infections in the U. 6 Serious consequences of listeria infection include gastrointestinal inflammation, sepsis, and central nervous system (CNS) involvement. 5 Its incidence rate is considerably low, and it is preventable and treatable However, it is associated with high hospitalization and mortality rates (20–50%). 4 Reportedly, LM is more prevalent during the summer. 3 LM can develop in the refrigerator over a long time and withstand large-scale temperatures (−0.4–45☌). 2 Listeria has a higher likelihood to contaminate uncooked or ready-to-eat food, such as meat, vegetables, milk, and dairy products. 1 LM is primarily transmitted to humans orally via food, accounting for 99% of cases. LM is an intracellular, aerobic and facultative anaerobic, Gram-positive bacterium, which was discovered accidentally in a prevalent infection in laboratory animals. Keywords: Listeria monocytogenes, listeriosis, pregnancy, neonate, infection, fever The necessary dietary guidance for pregnant women can reduce the incidence rate of pregnancy-related listeriosis. Neonatal Listeria infection is primarily transmitted through the placenta, which is a critical illness associated with a high mortality rate. Terminating the pregnancy to save the mother’s life should be considered if maternal and fetal conditions aggravate. Two weeks of high-dose intravenous amoxicillin (more than 6 g/day) is recommended for LM pregnant women without allergy. Listeriosis can be diagnosed using positive cultures from maternal or neonatal blood, neonatal cerebrospinal fluid (CSF), amniotic fluid, intrauterine mucosa, or the placenta. The early detection and diagnosis of pregnancy-associated listeriosis are significant since sensitive antibiotics are effective at enhancing the prognosis of newborns. This review collected clinical and empirical results regarding the mechanism, clinical manifestations, obstetrical outcome, diagnosis, treatment, vertical transmission, neonatal infection, and prevention of listeriosi according to articles published in PubMed from January 1, 1980, to March 20, 2021. If a pregnant woman exhibits symptoms, the performance is almost like influenza, such as fever, headache, diarrhea, myalgia, or other digestive-related symptoms. LM could occur in asymptomatic pregnant women however, fetal infection is a serious condition, entailing premature birth, abortion, sepsis, central nervous system (CNS) involvement, or even death. *These authors contributed equally to this workĭepartment of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of ChinaĪbstract: Listeria monocytogenes (LM) is an intracellular, aerobic and facultative anaerobic, Gram-positive bacterium, which is primarily transmitted to humans orally via food. Zhaoyun Wang, 1, * Xiaojing Tao, 1, * Shan Liu, 1, * Yutong Zhao, 1, * Xiuhua Yang 2ġDepartment of Clinical Medicine, China Medical University, Shenyang, Liaoning, People’s Republic of China 2Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China
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